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               NCT03887455

What follows is a brief summary of the Eisai Pharmaceuticals AHEAD 3-45 (CLARITY) trial of BAN2401, a monoclonal antibody that binds to large oligomers, called protofibrils, and neutralizes their damage to brain cells.

                   Sorry ... This trial is now fully randomized, closed for new enrollment. 


  • Drug administration -- IV infusion every 2 weeks     

  • Age range -- 50-90

  • MMSE range -- 22-30

  • Study Duration -- 18 mos.

  • Target population -- Mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD) and postive measure of brain amyloid pathology                                         

  • Mechanism of action --  blocks formation of active beta amyloid protein (BACE inhibition)

  • Randomization split -- 1:1,  active : placebo

  • Type(s) of imaging -- brain MRI, CT, amyloid PET, Tau PET


For more details on this specific trial, visit:


ClinicalTrials.gov
                                                                         
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